Protocols currently available through the
North Central Cancer Treatment Group

  • Go to Cancer Therapy Studies
  • Go to Control/Prevention Studies

    • Disease sites for
    Cancer Therapy Studies

    Breast CNS GI
    Hematology Lung Melanoma
    Unknown
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    Breast : Metastatic
    Study: E3108

    Participation via CTSU

    Description: A Phase II Prospective Trial Correlating Progression-Free Survival with CYP2D6 Activity in Patients with Metastatic Breast Cancer Treated with Single Agent Tamoxifen
    Limited Participants: None
    Notes:
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    Breast : Metastatic
    Study: N0733



    Description: Phase II Trial of Capecitabine and Lapatinib with or without IMC-A12 in Patients with HER2 Positive Breast Cancer Previously Treated with Trastuzumab and an Anthracycline and/or a Taxane
    Limited Participants: None
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    Breast : Metastatic
    Study: N0937



    Description: Phase II Trial of Brostallicin and Cisplatin in Patients with Metastatic Triple Negative Breast Cancer
    Limited Participants: None
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    Breast : Metastatic
    Study: N093B



    Description: Phase I/II study of Panobinostat (LBH589) and letrozole in patients with triple negative metastatic breast cancer
    Limited Participants: None
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    CNS : Brain
    Study: E3F05

    Participation via CTSU

    Description: Phase III Study of Radiation Therapy with or without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas
    Limited Participants: None
    Notes:
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    CNS : Brain
    Study: N0572



    Description: A Phase I/II Trial of Sorafenib and CCI-779 in Patients with Recurrent Glioblastoma
    Limited Participants: None
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    CNS : Brain
    Study: N0574



    Description: A Phase III Randomized Trial of the Role of Whole Brain Radiation Therapy in Addition to Radiosurgery in the Management of Patients with One to Three Cerebral Metastases
    Limited Participants: None
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    CNS : Brain
    Study: N0577


    Temporarily Closed

    Description: Phase III Intergroup Study of Radiotherapy versus Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma
    Limited Participants: None
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    CNS : Brain
    Study: N057K


    Temporarily Closed

    Description: Phase I/II Evaluation of Everolimus (RAD001), Radiation and Temozolomide (TMZ) Followed by Adjuvant Temozolomide and Everolimus in Newly Diagnosed Glioblastoma
    Limited Participants: None
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    CNS : Brain
    Study: N0872


    Temporarily Closed

    Description: Phase I/Randomized Phase II Double Blind Study of Either Dasatinib or Placebo Combined with Bevacizumab in Recurrent Glioblastoma
    Limited Participants: None
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    CNS : Brain
    Study: N0874



    Description: Phase I/II Study of Vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]), Temozolomide, and Radiation Therapy in Patients with Newly Diagnosed Glioblastoma
    Limited Participants: None
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    CNS : Brain
    Study: N0877



    Description: Phase I/Randomized Phase II Trial of Either Dasatinib or Placebo Combined with Standard Chemo-Radiotherapy for Newly Diagnosed Glioblastoma Multiforme (GBM)
    Limited Participants: None
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    CNS : Brain
    Study: N107C



    Description: A Phase III Trial of Post-Surgical Stereotactic Radiosurgery (SRS) Compared with Whole Brain Radiotherapy (WBRT) for Resected Metastatic Brain Disease
    Limited Participants: None
    Notes:
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    GI : Carcinoid
    Study: S0518

    Participation via CTSU

    Description: Phase III Prospective Randomized Comparison of Depot Octreotide Plus Interferon Alpha Versus Depot Octreotide Plus Bevacizumab (NSC #704865) in Advanced, Poor Prognosis Carcinoid Patients
    Limited Participants: None
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    GI : Colorectal
    Study: 80702

    Participation via CTSU

    Description: A Phase III Trial of 6 Versus 12 Treatments of Adjuvant FOLFOX plus Celecoxib or Placebo for Patients with Resected Stage III Colon Cancer
    Limited Participants: None
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    GI : Colorectal
    Study: N0949



    Description: Randomized Phase III Trial of mFOLFOX7 or XELOX Plus Bevacizumab Versus 5-Fluorouracil/Leucovorin or Capecitabine Plus Bevacizumab as First-line Treatment in Elderly Patients with Metastatic Colorectal Cancer
    Limited Participants: None
    Notes:
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    GI : Esophagus
    Study: N0849



    Description: Randomized Phase II Trial of Extended Neoadjuvant Therapy for Locally Advanced Adenocarcinoma of the Esophagus, Gastroesophageal Junction, or Gastric Cardia
    Limited Participants: None
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    GI : Islet Cell
    Study: 80701

    Participation via CTSU

    Description: Randomized Phase II Study of Everolimus Alone Versus Everolimus Plus Bevacizumab in Patients with Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors
    Limited Participants: None
    Notes:
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    GI : Pancreas
    Study: 80701

    Participation via CTSU

    Description: Randomized Phase II Study of Everolimus Alone Versus Everolimus Plus Bevacizumab in Patients with Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors
    Limited Participants: None
    Notes:
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    GI : Rectum
    Study: N1048



    Description: A Phase II/III Trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision
    Limited Participants: None
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    GI : Sm Bowel
    Study: N0543



    Description: A Phase II Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy for Advanced Small Bowel Adenocarcinoma
    Limited Participants: None
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    GI : Stomach
    Study: N0849



    Description: Randomized Phase II Trial of Extended Neoadjuvant Therapy for Locally Advanced Adenocarcinoma of the Esophagus, Gastroesophageal Junction, or Gastric Cardia
    Limited Participants: None
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    Hematology : CLL
    Study: N1087



    Description: Phase I/II Study of the Combination of Bendamustine, Rituximab and MK-2206 in the Treatment of Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
    Limited Participants: Essentia DuluthMC Arizona Sanford Fargo
    Notes:
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    Hematology : Non Hodgkin'
    Study: N078D



    Description: Phase I/II Trial of Rituximab, Cladribine, and Temsirolimus (RCT) Therapy in Newly Diagnosed Mantle Cell Lymphoma (MCL)
    Limited Participants: None
    Notes:
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    Hematology : Other Hem
    Study: E1F05
    Faxed Checklist Only

    Temporarily Closed

    Description: Phase II Study of Rituximab Given in Conjunction with Standard Chemotherapy in Primary Central Nervous System (CNS) Lymphoma
    Limited Participants: None
    Notes:
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    Hematology : Other Hem
    Study: N078D



    Description: Phase I/II Trial of Rituximab, Cladribine, and Temsirolimus (RCT) Therapy in Newly Diagnosed Mantle Cell Lymphoma (MCL)
    Limited Participants: None
    Notes:
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    Lung : NSCLC
    Study: S0819

    Participation via CTSU

    Description: A Randomized Phase III Study Comparing Carboplatin/Paclitaxel or Carboplatin/Paclitaxel/Bevacizumab with or without concurrent Cetuximab with Advanced Non Small Cell Lung Cancer
    Limited Participants: None
    Notes:
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    Lung : Sm. Cell
    Study: 30610

    Participation via CTSU

    Description: Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide
    Limited Participants: None
    Notes:
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    Lung : Sm. Cell
    Study: N0923



    Description: A Randomized Double-Blinded Phase II Study of NTX-010, a Replication-Competent Picornavirus, After Standard Platinum-Containing Cytroreductive Induction Chemotherapy in Patients With Extensive Stage Small Cell Lung Cancer
    Limited Participants: None
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    Melanoma
    Study: N0879



    Description: A Randomized Phase II Trial of Carboplatin, Paclitaxel, Bevacizumab, with or without Everolimus for Therapy of Metastatic Malignant Melanoma
    Limited Participants: None
    Notes:
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    Unknown
    Study: N0871



    Description: A Phase II Study of Carboplatin (CBDCA), Paclitaxel (TAXOL), and Everolimus (RAD001) in Previously Untreated Patients with Measurable Disease with Cancer of Unknown Primary (CUP)
    Limited Participants: None
    Notes:

    Disease sites for
    Cancer Control/Prevention Studies

    Breast GI GYN
    Head & Neck Multiple Other
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    Breast : Ca. Control
    Study: N10C1



    Description: Vaginal DHEA for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study
    Limited Participants: None
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    Breast : Ca. Control
    Study: N10C2



    Description: Double-Blind, Placebo-Controlled Study of Magnesium Supplements to Reduce Menopausal Hot Flashes
    Limited Participants: None
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    GI : Ca. Control
    Study: N08C9



    Description: Phase III, Randomized Study of Sulfasalazine versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy
    Limited Participants: None
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    GI : Ca. Control
    Study: N08CB



    Description: A Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium in Two Different Versions to Prevent Oxaliplatin-Induced Sensory Neurotoxicity
    Limited Participants: None
    Notes:
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    GYN : Mixed GYN
    Study: N10C1



    Description: Vaginal DHEA for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study
    Limited Participants: None
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    Head & Neck
    Study: N09C6



    Description: Randomized Double-Blind Study of Doxepin Rinse versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy with or without Chemotherapy
    Limited Participants: None
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    Multiple
    Study: N08C1



    Description: Paclitaxel-Associated Acute Pain Syndrome Natural History Study
    Limited Participants: None
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    Other : Ca. Control
    Study: N07C4



    Description: A randomized phase II trial evaluating two non-pharmacologic interventions in cancer survivors for the treatment of sleep-wake disturbances
    Limited Participants: None
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    Other : Ca. Control
    Study: N08C1



    Description: Paclitaxel-Associated Acute Pain Syndrome Natural History Study
    Limited Participants: None
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    Other : Ca. Control
    Study: N08C9



    Description: Phase III, Randomized Study of Sulfasalazine versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy
    Limited Participants: None
    Notes:
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    Other : Ca. Control
    Study: N08CB



    Description: A Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium in Two Different Versions to Prevent Oxaliplatin-Induced Sensory Neurotoxicity
    Limited Participants: None
    Notes:
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    Other : Ca. Control
    Study: N09C6



    Description: Randomized Double-Blind Study of Doxepin Rinse versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy with or without Chemotherapy
    Limited Participants: None
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    Other : Ca. Control
    Study: N10C1



    Description: Vaginal DHEA for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study
    Limited Participants: None
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    This report was created on Wednesday, February 8