All Open NCCTG Studies (Feb 9, 2012)

Cancer Therapy Studies

Site Protocol Description
Breast N0733 Phase II Trial of Capecitabine and Lapatinib with or without IMC-A12 in Patients with HER2 Positive Breast Cancer Previously Treated with Trastuzumab and an Anthracycline and/or a Taxane
Breast N0937 Phase II Trial of Brostallicin and Cisplatin in Patients with Metastatic Triple Negative Breast Cancer
Breast N093B Phase I/II study of Panobinostat (LBH589) and letrozole in patients with triple negative metastatic breast cancer
CNS N0572 A Phase I/II Trial of Sorafenib and CCI-779 in Patients with Recurrent Glioblastoma
CNS N0574 A Phase III Randomized Trial of the Role of Whole Brain Radiation Therapy in Addition to Radiosurgery in the Management of Patients with One to Three Cerebral Metastases
CNS N0577 Phase III Intergroup Study of Radiotherapy versus Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma
CNS N057K Phase I/II Evaluation of Everolimus (RAD001), Radiation and Temozolomide (TMZ) Followed by Adjuvant Temozolomide and Everolimus in Newly Diagnosed Glioblastoma
CNS N0872 Phase I/Randomized Phase II Double Blind Study of Either Dasatinib or Placebo Combined with Bevacizumab in Recurrent Glioblastoma
CNS N0874 Phase I/II Study of Vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]), Temozolomide, and Radiation Therapy in Patients with Newly Diagnosed Glioblastoma
CNS N0877 Phase I/Randomized Phase II Trial of Either Dasatinib or Placebo Combined with Standard Chemo-Radiotherapy for Newly Diagnosed Glioblastoma Multiforme (GBM)
CNS N107C A Phase III Trial of Post-Surgical Stereotactic Radiosurgery (SRS) Compared with Whole Brain Radiotherapy (WBRT) for Resected Metastatic Brain Disease
GI N0949 Randomized Phase III Trial of mFOLFOX7 or XELOX Plus Bevacizumab Versus 5-Fluorouracil/Leucovorin or Capecitabine Plus Bevacizumab as First-line Treatment in Elderly Patients with Metastatic Colorectal Cancer
GI N0849 Randomized Phase II Trial of Extended Neoadjuvant Therapy for Locally Advanced Adenocarcinoma of the Esophagus, Gastroesophageal Junction, or Gastric Cardia
GI N1048 A Phase II/III Trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision
GI N0543 A Phase II Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy for Advanced Small Bowel Adenocarcinoma
GI N0849 Randomized Phase II Trial of Extended Neoadjuvant Therapy for Locally Advanced Adenocarcinoma of the Esophagus, Gastroesophageal Junction, or Gastric Cardia
Hematology N1087 Phase I/II Study of the Combination of Bendamustine, Rituximab and MK-2206 in the Treatment of Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Hematology N078D Phase I/II Trial of Rituximab, Cladribine, and Temsirolimus (RCT) Therapy in Newly Diagnosed Mantle Cell Lymphoma (MCL)
Hematology N078D Phase I/II Trial of Rituximab, Cladribine, and Temsirolimus (RCT) Therapy in Newly Diagnosed Mantle Cell Lymphoma (MCL)
Lung N0923 A Randomized Double-Blinded Phase II Study of NTX-010, a Replication-Competent Picornavirus, After Standard Platinum-Containing Cytroreductive Induction Chemotherapy in Patients With Extensive Stage Small Cell Lung Cancer
Melanoma N0879 A Randomized Phase II Trial of Carboplatin, Paclitaxel, Bevacizumab, with or without Everolimus for Therapy of Metastatic Malignant Melanoma
Unknown N0871 A Phase II Study of Carboplatin (CBDCA), Paclitaxel (TAXOL), and Everolimus (RAD001) in Previously Untreated Patients with Measurable Disease with Cancer of Unknown Primary (CUP)

Cancer Control/Prevention Studies

Site Protocol Description
Breast N10C1 Vaginal DHEA for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study
Breast N10C2 Double-Blind, Placebo-Controlled Study of Magnesium Supplements to Reduce Menopausal Hot Flashes
GI N08C9 Phase III, Randomized Study of Sulfasalazine versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy
GI N08CB A Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium in Two Different Versions to Prevent Oxaliplatin-Induced Sensory Neurotoxicity
GYN N10C1 Vaginal DHEA for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study
Head & Neck N09C6 Randomized Double-Blind Study of Doxepin Rinse versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy with or without Chemotherapy
Multiple N08C1 Paclitaxel-Associated Acute Pain Syndrome Natural History Study
Other N07C4 A randomized phase II trial evaluating two non-pharmacologic interventions in cancer survivors for the treatment of sleep-wake disturbances
Other N08C1 Paclitaxel-Associated Acute Pain Syndrome Natural History Study
Other N08C9 Phase III, Randomized Study of Sulfasalazine versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy
Other N08CB A Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium in Two Different Versions to Prevent Oxaliplatin-Induced Sensory Neurotoxicity
Other N09C6 Randomized Double-Blind Study of Doxepin Rinse versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy with or without Chemotherapy
Other N10C1 Vaginal DHEA for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study

Ancillary Studies

Site Protocol Description
Breast N0832 Round-Robin Clinico-pathological Review of HER2 Testing in the Context of Adjuvant Therapy for Breast Cancer (N9831, BCIRG 006, and BCIRG 005)
Breast N0832 Round-Robin Clinico-pathological Review of HER2 Testing in the Context of Adjuvant Therapy for Breast Cancer (N9831, BCIRG 006, and BCIRG 005)
CNS 947252 Diagnostic and Prognostic Markers in High-Grade Glioma
CNS 947253 Diagnostic and Prognostic Markers in Low-Grade Gliomas
CNS N0477 Optimizing EGFR Inhibitor-Based Therapies for GBM
Multiple N0392 Assessment of Patient Satisfaction with Participation in Phase II/III NCCTG Clinical Trials